Depression is a clinical mood disorder in which a person experiences a persistent and significant lowering of mood, energy, and interest in daily life. It affects how a person thinks, feels, behaves, and functions in daily living.

Causes

Depression is caused by a combination of biological, psychological, and social factors.

  1. Biological Factors
  • Genetics: If there is a family history of depression it makes you vulnerable – though it’s not guaranteed.
  • Brain chemistry: Imbalances in serotonin, dopamine, and norepinephrine can affect mood regulation.
  • Medical conditions: Thyroid issues, chronic pain, hormonal changes, and neurological illnesses can contribute.
  1. Psychological Factors
  • Negative thinking patterns
  • Trauma or early-life adversity
  • Low self-esteem, inadequacy, incompetence, inferiority
  1. Social Factors
  • Stressful life events
  • Lack of social support
  • Chronic stress environments
  1. Lifestyle-Related Factors
  • Poor sleep
  • Substance use
  • Nutritional deficiencies
  1. Personality Factors
  • Sensitive, withdrawn, or melancholy personalities

Symptoms

  1. Emotional Symptoms
  • Persistent sadness, emptiness, loneliness
  • Irritability or anger
  • Hopelessness or helplessness
  • Loss of interest
  1. Physical Symptoms
  • Sleep changes
  • Appetite changes
  • Fatigue
  • Unexplained physical pains
  1. Cognitive Symptoms
  • Difficulty concentrating
  • Memory problems
  • Negative thoughts
  • Overthinking
  1. Behavioural Symptoms
  • Social withdrawal
  • Decline in performance
  • Lack of motivation
  • Neglecting hygiene or responsibilities
  1. Severe Symptoms
  • Thoughts of self-harm or suicide
  • Feeling life has no meaning
  • Unmanageable functioning

Diagnosis

  1. Clinical Interview
  • Symptoms, duration, impact
  • Past episodes
  • Medical & family history

2.Screening Tools

  • PHQ-9
  • HAM-D
  • BDI
  1. Functional Assessment
  • Work/academic functioning
  • Social withdrawal
  • Self-care
  • Suicide risk

Treatment

  1. Psychotherapy
  • CBT
  • IPT
  • Behavioural Activation
  • Psychodynamic Therapy
  1. Lifestyle Interventions
  • Exercise
  • Sleep regulation
  • Balanced diet
  • Sunlight exposure
  • Substance cessation
  • Structured routine
  1. Social Support
  • Family involvement
  • Support groups
  • Psychoeducation

4.Hospitalisation

  • For severe impairment or suicidality

Living with Depression

  • Start small
  • Create routine
  • Physical activity
  • Reach out for support
  • Avoid alcohol/substances
  • Yoga & pranayam
  • Break tasks into small steps
  • Journaling
  • Maintain sleep
  • Eat well
  • Be kind to yourself
  • Celebrate small wins
  • Avoid big decisions during lows
  • Stay consistent with treatment
  • Seek help if unsafe

Suggestions for Caregivers/Family

  • Listen without judgment
  • Validate emotions
  • Be patient

Practical Support

  • Help with tasks
  • Encourage structure
  • Accompany to appointments

Communication

  • Use supportive language
  • Avoid minimizing
  • Check in regularly

Encouragement

  • Encourage professional help
  • Support healthy habits
  • Celebrate progress

Understanding

  • Educate yourself
  • Recognise symptoms
  • Understand lack of motivation is not laziness

Crisis Support

  • Take suicidal statements seriously
  • Stay with them if unsafe
  • Remove harmful objects

 Self-Care for Caregivers

  • Set boundaries
  • Seek help if overwhelmed

FAQ’s

What is depression?

A clinical mood disorder with persistent sadness and functional impairment.

Sadness is temporary; depression is long-lasting.

Low mood, fatigue, appetite/sleep changes, withdrawal.

Combination of genetic, biological, psychological, and environmental.

Yes

Not always

Varies widely.

Yes

No.

Yes.

Symptoms >2 weeks or suicidal thoughts.

Listening, supporting, encouraging treatment.